SIICA 2020

E-Poster

Please click here to download the E-Poster Session and here to download the Abstract Book.

Do not forget to take part into the two interactive poster sessions, organized by SIICA Junior Faculty, scheduled as follows:

Session 1: May 26th 18:30 - 19:15

Autoimmunity And Allergies
Covid19
Innate Immunity
Monocytes and Macrophages
Nk Cells And Ilc
T-cells

Session 2: May 26th 19:15-20:00

B-lymphocites
Cell Signaling
Infections And Immunity
Mast Cells And Granulocytes
Neuroimmunology
Primary Immunodeficiencies
Tumor Immunology

Please, click on the GoogleMeet Event button to access the two interactive sessions and virtually meet the presenter!

Main Topics

E-POSTER - 1. AUTOIMMUNITY AND ALLERGIES

Antibiotic-associated dysbiosis affects the ability of the gut microbiota to control intestinal inflammation upon faecal microbiota transplantation in experimental colitis models

Presenter: Francesco Strati

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GATA6 deficiency leads to epithelial barrier dysfunction and enhances susceptibility to gut inflammation

Presenter: Federica Laudisi

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Hypermotility of CD8+ T cells in Ankylosing Spondylitis subjects: cause or effect of a chronic inflammation?

Presenter: Giorgia Paldino

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Diving into inflammation: a pilot study exploring the dynamics of the immune-microbiota axis in ileal tissue layers of patients with Crohn’s disease.

Presenter: Edda Russo

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Targeted nanoparticles as a theranostic tool for the management of complement-mediated vascular thrombosis

Presenter: Paolo Macor

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Elucidating the extracellular vesicle-associated determinants modulating Foxp3 expression and suppressive function of T regulatory cells in multiple sclerosis

Presenter: Anne Lise Ferrara

Phenotypical and functional characterization of Foxp3Exon2+ Treg cell subset in the tumor microenvironment of breast cancer subjects

Presenter: Rosaria Prencipe

Immuno-metabolic analysis in new-onset psoriasis defines clusters of correlation and indicates a candidate diagnostic signature

Presenter: Eva Reali

Platelet phagocytosis controls the  accumulation of microparticles in the plasma of patients with systemic sclerosis

Presenter: Angelo A Manfredi

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Self-reactive T cells in an autoimmune model of psoriasis-like inflammation.

Presenter: Eva Reali

Expression of CD26 (Dipeptidil-peptidasi IV) in muscle and blood cells of patients with idiopathic inflammatory myopathies.

Presenter: Angelo A Manfredi

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Monitoring of biological drugs in the treatment of autoimmune rheumatic diseases: advantages and limitations.

Presenter: Sara La Palombara

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Natural Killer cells as possible mediators of Graves’ disease cure

Presenter: Daniela Gallo

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Janus-faced liposomes as therapeutic tools to drive T suppressor phenotype in multiplesclerosis.

Presenter: Renato Falcicchia

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E-POSTER - 2. B-LYMPHOCITES

Targeted chitosan nanobubbles: new approach for anti-microRNA-based therapy in Burkitt lymphoma models.

Presenter: Sara Capolla

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Three-dimensional in-vitro model for the study of Diffuse Large B cell Lymphoma antineoplastic treatments

Presenter: Jessica Ceccato

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CRISPR/Cas9 and mRNA-based technology for gene editing and expression in human B cells

Presenter: Anna Kabanova

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Preclinical development of a modular nano-platform for the treatment of B-cells malignancies

Presenter: Sara Bozzer

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The dialogue between B cells and Mast cells sustain IgA response in the inflamed intestine

Presenter: Silvia Tonon

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Immune complexes sustain CpG-induced proliferation of rheumatoid factor-specific B cells in hepatitis C virus-cured mixed cryoglobulinemia by reversing TLR tolerance

Presenter: Marcella Visentini

E-POSTER - 3. CELL SIGNALING

Class IA phosphoinositide 3-kinases regulate subcellular and functional dynamics of indoleamine 2,3-dioxygenase 1

Presenter: Maria Teresa Pallotta

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E-POSTER - 4. COVID19

Seroprevalence of SARS-CoV2 in IBD patients treated with biological therapy

Presenter: Federica Facciotti

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Cytokine and immune cell profiling in peripheral blood from patients with COVID-19 treated with tocilizumab

Presenter: Martina Bonacini

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Immunophenotype analysis in patients with SARS-CoV-2 infection admitted to the IRCCS Sacro Cuore - Don Calabria Hospital

Presenter: Sara Caldrer

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Activation, trafficking and turnover of peripheral NK cells in COVID-19 patients

Presenter: Carola Perrone

High-Throughput Single-Cell Analysis Revealed Transcriptional Response of Dendritic Cells Subsets During Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Presenter: Giulia Protti

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Tocilizumab in Covid-19: an integrated approach to evaluate treatment response.

Presenter: Lorenzo Salvati

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Cell-mediated and humoral adaptive immune responses to SARS-CoV-2 are lower in asymptomatic than symptomatic COVID-19 patients, both during infection and after recovering

Presenter: Laura Maggi

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Effects of two pharmacological approaches on cytokine storm in severe COVID-19 patients

Presenter: Giulia Lamacchia

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CXCL-10 levels at hospital admission represent potential predictor of COVID-19 outcome

Presenter: Nicola I Lore'

SARS COV-2 childhood infection immunopathology: the counterbalance of Th2/Treg compartment and the protective role of immunoregulatory profile.

Presenter: Gabriele Di Sante

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Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases

Presenter: Eva Piano Mortari

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Induction and maintenance of B-cell memory after SARS-CoV-2 vaccination in a population of hospital workers

Presenter: Ane Fernandez Salinas

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E-POSTER - 5. INFECTIONS AND IMMUNITY

Dissecting the role of IFNγ in the antiviral CD4+ T cells fate

Presenter: Eleonora Sala

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Role of platelets in tuberculosis pathogenesis

Presenter: Marco Pio La Manna

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Ex vivo stimulation of Mycobacterium tuberculosis specific TCD8+ HLAE restricted cells by recombinant detoxified Bordetella  pertussis toxoid

Presenter: Giusto Davide Badami

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HOST-PATHOGEN INTERFACE IN STAPHYLOCOCCUS AUREUS-DEPENDENT OSTEOMYELITIS: EMERGING ROLES OF THE LONG PENTRAXIN PTX3

Presenter: Raffaella Parente

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The serotonin pathway of tryptophan metabolism regulates inflammation in the lung

Presenter: Fiorella D'Onofrio

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The modulation of Toll like Receptors/CD44 axis regulates clinical features of experimental and human Multiple Sclerosis.

Presenter: Maria Tredicine

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Xenobiotic receptors cross-talk in lung infection and inflammation

Presenter: Ilaria Santarelli

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E-POSTER - 6. INNATE IMMUNITY

Innate immune regulation of the inflammatory process

Presenter: Ivan Zanoni

Activated Phosphoinositide 3-Kinase Delta Syndrome 1: clinical and immunological data from an Italian cohort of eight patients

Presenter: Giulio Tessarin

Molecular and phenotypical analysis of immunosuppressive neutrophils from G-CSF-treated donors and cancer patients

Presenter: Francesca Pettinella

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Functional HCMV-controlling NKG2C+ NK cells are included in the progeny of newly characterized inflammatory Common Lymphocyte Precursors

Presenter: Andrea De Maria

Longitudinal study of C1q and anti-C1q auto-antibodies in homologous and heterologous pregnancies

Presenter: Chiara Agostinis

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Effects of whole-body cryotherapy on the innate immune response in football players

Presenter: Marco Mattioli

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Role of CCRL2 in the regulation of CXCR4- and CXCR2-dependent neutrophil homing

Presenter: Ilaria Barbazza

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Human neutrophils activated by TLR8 agonists, with or without IFNγ, synthesize and release EBI3, but not IL-12, IL-27, IL-35, or IL-39

Presenter: Elisa Gardiman

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SINGLE NUCLEOTIDE POLYMORFISMS IN IL1RN GENE AFFECT THE RESPONSE TO ANAKINRA IN SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS AND ALTERS IL1RN AND IL1B GENE EXPRESSION

Presenter: Marianna Nicoletta Rossi

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Psoriasis-related miR203 activates NK cells by a complex pDC/monocyte/NK cell crosstalk

Presenter: H Oanh Nguyen

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Differential expression and regulation of MS4A molecules in myeloid cells in physiological and pathological conditions

Presenter: Rita Silva-Gomes

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E-POSTER - 7. MAST CELLS AND GRANULOCYTES

Vascular Endothelial Growth Factors and Angiopoietins as New Players in Mastocytosis

Presenter: Simone Marcella

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Neutrophils and Neutrophil Extracellular Traps in Severe Bronchial Asthma

Presenter: Luca Modestino

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Characterization of the transcriptional profile of circulating granulocytes in Chronic Obstructive Pulmonary Disease

Presenter: Barbara Mariotti

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E-POSTER - 8. MONOCYTES AND MACROPHAGES

Macrophage-polarizing stimuli differentially modulate the inflammatory profile induced by the secreted phospholipase A2 group IA in human lung macrophages

Presenter: Anne Lise Ferrara

Deciphering the fate of slan + -monocytes in human tonsils by gene expression profiling

Presenter: Francisco Miguel Angel Bianchetto Aguilera

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Role of NAMPT/Visfatin and adipokines cluster in inflammation-associated Osteoarthritis

Presenter: Mauro Passari

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E-POSTER - 9. NEUROIMMUNOLOGY

AMYOTROPHIC LATERAL SCLEROSIS: THE ENGAGMENT OF NATURAL KILLER CELLS

Presenter: Anna Maria Corsale

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Intracellular content of Superoxide Dismutase-1 in T lymphocytes associates with increased regulatory T cells in Multiple Sclerosis individuals undergoing immune-modulating treatment.

Presenter: Valentina Rubino

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The use of arundic acid as novel therapy for multiple sclerosis

Presenter: Chiara Camponeschi

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Gene Expression Profiling Identifies Specific Signatures in Peripheral Blood Monocytes of Multiple Sclerosis Patients

Presenter: Ilenia Savinetti

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E-POSTER - 10. NK CELLS AND ILC

Peripheral blood Natural Killer cells in prostate cancer patients acquire the decidual-like CD56brightCD9+CD49a+ phenotype and support angiogenesis in vitro, acting on endothelial cells and polarizing macrophages toward the M2-like/TAM phenotype.

Presenter: Antonino Bruno

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Education of murine Natural Killer Cells – cell biological and molecular correlates

Presenter: Lucia Carmela Passacatini

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FREQUENCIES AND FUNCTIONAL PROPERTIES OF INNATE LYMPHOID CELLS ARE ALTERED IN MELANOMA PATIENTS AND MODULATED BY IMMUNE CHECKPOINTS INHIBITORS

Presenter: Costanza Maria Cristiani

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Deciphering the role of NK cells/ILC1 in liver metastasis from colorectal cancer

Presenter: Eleonora Russo

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Immunomodulatory properties of extracellular vesicles carrying NKG2D activating ligands:  a double edge sword in cancer immunosurveillance

Presenter: Elisabetta Vulpis

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Dissecting roles for type 1 innate lymphoid cells in colitis and colitis-induced colorectal cancer

Presenter: Gianluca Scarno

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Granzyme A and CD160 expression defines distinct ILC1 subsets in the mouse liver

Presenter: Chiara Di Censo

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Chimeric Antigen Receptor Engineered NK-92 Cells against Prostate specific membrane antigen: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Prostate Cancer Cells

Presenter: Gaia Zuccolotto

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E-POSTER - 11. PRIMARY IMMUNODEFICIENCIES

A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly

Presenter: Nagaja Capitani

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ALTERED NKG2D/NKG2D-LIGAND PATHWAY IN ATAXIA-TELANGIECTASIA PATIENTS

Presenter: Margherita Doria

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CTLA-4 Haploinsufficiency: clinical and immunological data from a single center cohort of patients

Presenter: Stefano Rossi

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Whole-exome sequencing in Common Variable Immunodeficiency

Presenter: Boaz Palterer

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E-POSTER - 12. T-CELLS

Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming

Presenter: Giorgia De Simone

miR-21 sustains CD28-signalling and facilitates low affinity T-cell responses at the expense of self-tolerance

Presenter: Maya Fedeli

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CD28-Associated Class 1A PI3K Regulates IL-22–Mediated Epithelial Barrier functions in human T lymphocytes.

Presenter: Martina Kunkl

Identification of functional subsets of T lymphocytes based on the expression of immune-checkpoints, in juvenile idiopathic arthritis

Presenter: Anna Vanni

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The intraflagellar transport protein IFT20 recruits ATG16L1 to early endosomes to promote autophagosome formation in T cells

Presenter: Fabrizia Zevolini

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CD8+ T stem cell memory  cells in Tuberculosis

Presenter: Mojtaba Shekarkar azgomi

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E-POSTER - 13. TUMOR IMMUNOLOGY

PD-1 signaling regulates Drp1-dependent mitochondrial fission in tumor-infiltrating T cells.

Presenter: Luca Simula

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Human Intestinal and Circulating invariant Natural Killer T cells are cytotoxic against Colorectal Cancer cells via the Perforin/Granzyme pathway

Presenter: Angelica Diaz Basabe

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CD8+ T cell dynamics within hepatocellular carcinoma

Presenter: Bianca Partini

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Inflammatory HMGB1 modulation in primary and metastatic breast cancer patients treated with different therapy

Presenter: Fabio Scirocchi

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Circulating Immune profile of uveal melanoma patients: impact on clinical outcome

Presenter: Ilaria Grazia Zizzari

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Regulatory T cells capture iron through the transferrin receptor during physiological and tumor-associated expansion

Presenter: Ilenia Pacella

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Steady IFNα therapy prevents the development of colorectal liver metastasis through the activation of liver sinusoidal endothelial cells

Presenter: Giovanni Sitia

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ROLE OF CD36 IN MULTIPLE MYELOMA PROGRESSION

Presenter: Eleonora Malerba

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Interleukin-9 secreted by leukemic cells from chronic lymphocytic leukemia patients promotes cytotoxic T cell exhaustion.

Presenter: Vanessa Tatangelo

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C1q-hyaluronic acid matrix as an in vitro model for mimicking the response to chemotherapeutic drugs in malignant pleural mesothelioma

Presenter: Andrea Balduit

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ABERRANT WNT/β-CATENIN SIGNALING AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CARCINOMA

Presenter: Rossella Fasano

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Stearoyl-coenzyme A desaturase 1 and Tregs metabolic adaptations in hepatocellular carcinoma

Presenter: Alessandra Rossi

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P53 reactivation by PEG-PLA copolymer nanoformulation improves Natural Killer cell targeting of melanoma cells.

Presenter: Cinzia Garofalo

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Dual targeting of cancer and suppressive myeloid cells by tumor-redirected iNKT cells and antigen-carrying microparticles

Presenter: Gloria Delfanti

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In pancreatic cancer patients chemotherapy, but not immune checkpoint blockade, rescues effector T cell response to tumor associated antigens

Presenter: Silvia Brugiapaglia

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Neutrophil PD-L1 expression as a novel predictive biomarker for IV stage melanoma patients

Presenter: Leonardo Cristinziano

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Donor-unrestricted targeting of CD1c-expressing leukemia by T cells engineered with lipid-specific TCR

Presenter: Michela Consonni

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Targeting Toll-Like Receptor 2 to impair breast cancer progression and resistance to chemotherapy

Presenter: Laura Conti

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Role of calcineurin in affecting tumor growth and the formation of the tumor microenvironment

Presenter: Mihai Valache

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Targeting the cystine/glutamate antiporter xCT and Mutant-p53 synergistically hinders breast cancer progression

Presenter: Antonino Di Lorenzo

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Prognostic value of circulating immunologic parameters in NSCLC patients treated with nivolumab: a pilot study

Presenter: Manuela Capone

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Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression

Presenter: Elena Magrini

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Investigating the cystine/glutamate antiporter xCT in the interaction between mammary cancer and the immune system

Presenter: Roberto Ruiu

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Identification of Teneurin 4 as a novel cancer stem cell-associated antigen and potential biomarker

Presenter: Giulia Peppino

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EMERGING IMMUNOLOGICAL CHECKPOINTS PUT THE BRAKES ON MELANOMA INFILTRATING γδ T CELLS

Presenter: Marta Di Simone

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MATERNAL IMMUNIZATION AGAINST ANAPLASTIC LYMPHOMA KINASE: A NEW WEAPON AGAINST NEUROBLASTOMA

Presenter: Giuseppina Barutello

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A chimeric Human/Dog DNA vaccine against the Chondroitin Sulfate Proteoglycan 4 reveals potential therapeutic effects for the treatment of melanoma

Presenter: Federica Riccardo

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CSPG4 immune-targeting as novel strategy for the treatment of osteosarcoma

Presenter: Lidia Tarone

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Nutlin-3a enhances Natural Killer cell-mediated killing of neuroblastoma by restoring p53-dependent expression of ligands for NKG2D and DNAM-1 receptors

Presenter: Loredana Cifaldi

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Macrophage-driven inflammation in Malignant Pleural Mesothelioma: role of Osteopontin and GPNMB in tumor progression

Presenter: Elisabeth Digifico

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A Disintegrin And Metalloproteinases inhibitors direct effects and brentuximab vedotin enhancement in Hodgkin’s lymphoma 3-dimensional models.

Presenter: Roberta Pece

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Immune microenvironment profiling of breast cancer brain metastases using multiplex immunofluorescence

Presenter: Anna Tosi

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Tumor microenvironment characterization of Human papillomavirus-positive and -negative oropharyngeal squamous cell carcinomas

Presenter: Beatrice Parisatto

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Caspase-11 is at the crossroad between smoke-induced inflammation and lung cancer in mice.

Presenter: Chiara Colarusso

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Patient-derived colon epithelial organoids as a three dimensional model to study Vδ2T cell-mediated immune response in colorectal carcinomas.

Presenter: Federico Villa

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Role of tumor-associated macrophages in immune evasion in colorectal cancer

Presenter: Annica Barizza

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hMENA11a loss activates Type I IFN and inflammatory pathways, and in turn PD-L1 expression, by activating the viral sensor RIG-I

Presenter: Paola Trono

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A novel and effective hyaluronic acid-based vaccination strategy for the prevention and treatment of HER2/neu-overexpressing breast cancers

Presenter: Debora Carpanese

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